The divergent MBFV-related viruses are probably significantly under sampled to date and provide new information on the variety, properties and evolution of vector- borne flaviviruses. Serological cross-reactions of MBFV-related viruses with other flaviviruses and their potential for vector- borne transmission require further characterization. Phylogenetic analyses separated the MBFV-related viruses isolated in Africa, the Middle East and South America from those isolated in Europe and Asia. In this overview of MBFV-related viruses we conclude that they differ from the ISFs genetically and antigenically. Unlike the MBFV that infect both vertebrates and mosquitoes, the MBFV-related viruses appear to be specific to mosquitoes similar to the insect-specific flaviviruses (ISFs). We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designated as Ilomantsi virus (ILOV). Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. Sironen, Tarja Kuivanen, Suvi Putkuri, Niina Kurkela, Satu Harbach, Ralph E. Huhtamo, Eili Cook, Shelley Moureau, Gregory UzcÃ¡tegui, Nathalie Y. Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses

Isfv physiology